A common sexual side effect of SSRIs that can lead to discontinuation is?

• A. Loss of libido or sexual dysfunction.
• B. Weight gain.
• C. Increased appetite.
• D. Enhanced sexual performance.

Answer: (A)

SSRIs often impact sexual function because increased serotonin can dampen sexual desire and arousal. The most common and distressing consequence is loss of libido and sexual dysfunction, including trouble with arousal and orgasm. This side effect is frequently reported and can lead people to discontinue the medication, since it directly affects intimate life and overall quality of life. The underlying idea is that serotonin elevation can blunt dopamine-driven motivation and arousal pathways, making sexual activity harder or less pleasurable.

Weight gain or increased appetite are metabolic changes that can occur with some antidepressants but are not primarily sexual effects, and enhanced sexual performance is not aligned with how SSRIs typically affect sexual function.